Male carriers of HLA-C*04:01 have increased risk of cardiac injury in COVID-19

Identification of factors that lead to the severe clinical course COVID-19 is crucial for timely allocation resources. The purpose this study was evaluate possible sex differences in cardiac injury associated with HLA-C*04:01. High sensitivity troponin T on admission (hs-TnTa) and maximum high (hs-TnTmax) were used assess patients (n = 435). We tested association elevated hs-TnT HLA-C* 04:01 evaluated potential sex-specific differences. An between hs-TnTa severity identified. In addition, our revealed hs-TnTmax higher men who carriers HLA-C*04:01 compared without risk allele. Male developed hs-TnTmax, suggesting a larger extent injury. This suggests presence different pathomechanisms based sex.